TAZ WW Domain-Mediated Regulation of Gluconeogenesis and Tumorigenesis in Hepatocellular Carcinoma through Interaction with the Glucocorticoid Receptor

Hongxiang Huang; Jinhong Chen; Xingyu Tao; Peiyuan Zhong; Yanqiu Meng; SuJuan Peng; Wanying Luo; Zhiyong He; Shuai Luo; Xie Zhu; Zhihui Lu; Li Chen; Yangyang Liu

doi:10.3803/enm.2025.2471

February 10, 2026Endocrinology and MetabolismOpen Access

TAZ WW Domain-Mediated Regulation of Gluconeogenesis and Tumorigenesis in Hepatocellular Carcinoma through Interaction with the Glucocorticoid Receptor

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Key Points

The aim is to investigate how TAZ regulates gluconeogenesis and tumor growth in hepatocellular carcinoma via its interaction with the glucocorticoid receptor.
Analyzed the effects of TAZ knockdown on tumor progression and gluconeogenesis.
Examined TAZ's interaction with the glucocorticoid receptor (GR).
Assessed transcriptional activity of GR on gluconeogenic gene promoters.
TAZ knockdown significantly reduced tumor progression.
TAZ enhanced gluconeogenesis and promoted tumor growth.
TAZ suppresses GR's transcriptional activity on gluconeogenic genes.

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Implication

Demonstrates that TAZ influences gluconeogenesis and tumor progression through glucocorticoid receptor interaction, suggesting novel targets for cancer therapies.

Abstract

TAZ modulates gluconeogenesis and accelerates tumor growth, whereas its knockdown attenuates tumor progression. TAZ interacts with GR, suppressing its transcriptional activity on gluconeogenic gene promoters.

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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/698ebf1d85a1ff6a93016449 https://doi.org/10.3803/enm.2025.2471

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TAZ WW Domain-Mediated Regulation of Gluconeogenesis and Tumorigenesis in Hepatocellular Carcinoma through Interaction with the Glucocorticoid Receptor

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

TAZ WW Domain-Mediated Regulation of Gluconeogenesis and Tumorigenesis in Hepatocellular Carcinoma through Interaction with the Glucocorticoid Receptor

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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