What question did this study set out to answer?

To evaluate the performance of the Collagen-Induced Platelet Aggregation Level (CPAL) score in monitoring aspirin effects.

February 13, 2026Clinical Laboratory0 citations

Evaluation of Collagen-Induced Platelet Aggregation Level Score Using an Automated Coagulation Analyzer

KKKeisuke Kitano TSTasuku SakayoriUniversity of Tsukuba YTYukari Tsuboi

Key Points

To evaluate the performance of the Collagen-Induced Platelet Aggregation Level (CPAL) score in monitoring aspirin effects.
Used an automated coagulation analyzer for measurements.
Compared CPAL with AA-MA and ARU from VerifyNow.
Analyzed variable aspirin concentrations to assess correlation results.
CPAL showed good correlation with AA-MA scores.
CPAL did not correlate well with ARU scores.
Performance of CPAL was consistent across different aspirin concentrations.

Abstract

CPAL exhibits acceptable performance. It showed good correlation with AA-MA but not with the ARU of VerifyNow, which changed with slight differences in aspirin concentration. CPAL is a new platelet aggregation scoring system that may be used to monitor the effects of aspirin using an automated coagulation analyzer.

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