Key result
Ultraslow low-dose thrombolysis can safely restore valve function in obstructive HALT when reoperation is prohibitive.
Why the study?
Hypoattenuated leaflet thickening (HALT) is an important cause of bioprosthetic valve dysfunction after transcatheter aortic valve replacement and its management in complex valve-in-valve cases is challenging.
Does ultraslow, low-dose alteplase followed by apixaban improve prosthetic valve obstruction in a patient with HALT after complex TAVR?
Case Report (n=1)
Does ultraslow, low-dose alteplase followed by apixaban improve prosthetic valve obstruction in a patient with HALT after complex TAVR?
Ultraslow, low-dose thrombolysis followed by anticoagulation can safely restore valve function in obstructive HALT when reoperation is prohibitive.
May warrant consideration when reoperation prohibitive; hypothesis-generating for obstructive HALT after valve-in-valve TAVR.
BACKGROUND: Hypoattenuated leaflet thickening (HALT) is an important cause of bioprosthetic valve dysfunction after transcatheter aortic valve replacement. CASE SUMMARY: A woman in her mid-70s developed 1 week of exertional dyspnea and chest tightness 5 years after a complicated transcatheter aortic valve replacement in which a migrated 26-mm Medtronic Evolut PRO+ valve was snared into the distal ascending aorta, and a second 26-mm Evolut PRO+ valve was placed across the annulus. Echocardiography showed severe prosthetic valve obstruction, and computed tomography angiography revealed overlapping frames with leaflet hypoattenuation consistent with HALT. She received ultraslow, low-dose alteplase over 48 hours, followed by apixaban, resulting in marked improvement (mean gradient decreased from 66 to 28 mm Hg). DISCUSSION: Although HALT may resemble structural valve degeneration, it can respond well to medical therapy in selected patients with high procedural risk. TAKE-HOME MESSAGE: Ultraslow, low-dose thrombolysis followed by anticoagulation can safely restore function in obstructive HALT when reoperation is prohibitive.
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Shrestha et al. (2026) conducted a case report in Obstructive Hypoattenuated Leaflet Thickening (HALT) after TAVR (n=1). Ultraslow, low-dose alteplase followed by apixaban was evaluated on Mean gradient. Ultraslow, low-dose alteplase followed by apixaban successfully treated obstructive hypoattenuated leaflet thickening, decreasing the mean gradient from 66 to 28 mm Hg.
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