What question did this study set out to answer?

This review aims to evaluate evidence linking dietary intake and nutritional interventions to metabolic profiles in pediatric populations.

Association Between Diet and Metabolome in Childhood and Adolescence: A Systematic Review

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Systematic review evaluates dietary impacts on metabolic profiles in children and adolescents, suggesting insights for healthier eating.

This review aims to evaluate evidence linking dietary intake and nutritional interventions to metabolic profiles in pediatric populations.
Conducted a systematic search in PubMed, Cochrane, and Embase databases for related studies.
Included randomized clinical trials and observational studies focusing on children and adolescents.
Analyzed data from 8 studies with a total of 5992 participants across 12 countries.
Identified positive associations between adherence to the Mediterranean diet and metabolites like hippurate and proline betaine.
Found inverse associations between high intake of ultra-processed foods and levels of branched-chain amino acids.
Demonstrated the potential of metabolomics for validating dietary biomarkers in pediatric populations.

Gispert-Llauradó et al. (2025) studied this question.

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