What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

To assess the role of hypophosphatemia as a biomarker indicating metabolic intolerance to nutrition in critically ill children.

February 14, 2026Critical CareOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Secondary analysis reveals hypophosphatemia interacts with parenteral nutrition exposure, highlighting risks of infection and clinical outcomes.

To assess the role of hypophosphatemia as a biomarker indicating metabolic intolerance to nutrition in critically ill children.
Secondary analysis of the PEPaNIC RCT including 1440 critically ill children.
Evaluated early and late parenteral nutrition interventions in relation to hypophosphatemia.
Analyzed outcomes like infections, PICU dependency, and mortality rates.
19.9% and 27.5% developed hypophosphatemia on PICU days 1 and 2, respectively.
On day 2, hypophosphatemia increased risk of new infections and earlier PICU discharge.
Higher 90-day mortality associated with hypophosphatemia when exposed to early parenteral nutrition.

Vanhorebeek et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Secondary analysis reveals hypophosphatemia interacts with parenteral nutrition exposure, highlighting risks of infection and clinical outcomes.