This research demonstrates enhanced nerve regeneration in models using neural crest-like cells, suggesting a new approach for peripheral nerve repair.
NCAM-positive NCLCs derived from hiPSCs enhance peripheral nerve regeneration through vascularization and Schwann cell-mediated remyelination, resulting in structural and functional recovery equivalent to autografts. This strategy offers a safe, scalable alternative to donor nerve harvest, and integration with bioengineered conduits could further expand clinical applicability in peripheral nerve reconstruction.
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Amemiya et al. (2026) studied this question.
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