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February 14, 2026Journal of Surgical Research0 citationsOpen Access

Survival of Patients With Noncolorectal Non-Neuroendocrine Liver Metastases: A Nationwide Cohort Study From the Danish Liver Cancer Group

LMLauge Hjorth MikkelsenRigshospitaletPLPeter Nørgaard LarsenUniversity of CopenhagenLKLucas Alexander KnøflerCopenhagen University Hospital

Key Points

  • The study aims to evaluate survival outcomes for patients with noncolorectal non-neuroendocrine liver metastases and the role of surgery.
  • Nationwide cohort analysis of patients with liver metastases.
  • Assessment of age, WHO performance status, and primary cancer type as prognostic factors.
  • Comparison of survival rates between surgical and non-surgical patients.
  • Patients undergoing surgery showed improved survival compared to those who did not.
  • Age and WHO performance status were significant predictors of survival.
  • Causal effects of surgery on survival could not be firmly established due to potential confounding factors.

Abstract

NCNNLM carries a poor prognosis. Surgery of liver metastasis is associated with improved survival with age, WHO performance status, and primary cancer type serving as important prognostic factors. However, from our study we could not establish a causal effect of surgery and confounding by indication is likely.

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Cite This Study

Mikkelsen et al. (2026) studied this question.

synapsesocial.com/papers/699010382ccff479cfe56c24https://doi.org/10.1016/j.jss.2026.01.006
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