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February 14, 2026Journal of Biomaterials Science Polymer Edition

Development and evaluation of a chitosan-coated alginate microsphere system for Thymus vulgaris and Calendula officinalis oil delivery

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Authors

EGElif Hatice GürkanCÇCengizhan Çakır

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Overview

Develops a system for controlled delivery of essential oils in gastrointestinal conditions, suggesting enhanced therapeutic potential.

Key Points

  • The research focuses on creating a delivery system for Thymus vulgaris and Calendula officinalis oils to improve stability and release under gastrointestinal conditions.
  • Developed microspheres using water-in-oil emulsification and external gelation.
  • Characterized microspheres with scanning electron microscopy and Fourier-transform infrared spectroscopy.
  • Evaluated swelling behavior in simulated gastric and intestinal fluids.
  • Determined encapsulation efficiency and loading capacity using UV-visible spectrophotometry.
  • Conducted in vitro release studies following kinetic models.
  • Optimized microspheres had an average diameter of 525 ± 25 µm.
  • Encapsulation efficiencies for Thymus vulgaris oil ranged from 72 ± 1.5% to 81 ± 1.8%, and for Calendula officinalis oil from 68 ± 2.0% to 72 ± 1.7%.
  • Swelling ratios increased to 250 ± 5% at pH 6.8.
  • Release studies indicated controlled release behaviors consistent with Higuchi and Korsmeyer-Peppas models.

Cite This Study

Gürkan et al. (2026) studied this question.

synapsesocial.com/papers/699010942ccff479cfe56efahttps://doi.org/10.1080/09205063.2026.2625840
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