Complement Inhibition for Acute Neuromyelitis Optica Spectrum Disorder Attacks

Paulus S. Rommer; Wei Jiang; Julia Nolte; Takahisa Mikami; J. De Seze; Pedro Ortiz Sánchez; Asaff Harel; Samir Alkabie; Kimihiko Kaneko; Philippe Bilodeau; Tatsuro Misu; Laurent Kremer; Kévin Bigaut; Frank Leypoldt; Orhan Aktas; Marius Ringelstein; Volker Siffrin; Lin-Jie Zhang; Hengri Cong; Mallory Lowe; Paula Barreras; Haiwen Chen; Amanda L. Piquet; Elias Sotirchos; Ryan Kammeyer; Jadyn Zook; Jeffrey L. Bennett; Thomas Berger; Kazuo Fujihara; Michael Levy; Fu-Dong Shi; F. Paul

doi:10.1212/nxi.0000000000200548

Key Points

To evaluate the effects of C5 complement inhibitors on disability in NMOSD patients during acute attacks.
Retrospective analysis of NMOSD patients
Assessment of disability improvement using complement inhibitors
Focus on eculizumab and ravulizumab administration timing
Complement inhibitors linked to improved disability scores
Treatment administered during or shortly after relapse showed positive effects
Class IV evidence supports using eculizumab or ravulizumab in acute management

Implication

Retrospective case series shows complement inhibitors improve disability during acute NMOSD relapses, indicating potential for treatment.

Abstract

This retrospective case series provides Class IV evidence that the C5 complement inhibitors eculizumab or ravulizumab may improve disability in patients with NMOSD when given during or shortly after acute relapse.

Discussion

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Cite This Study

Rommer et al. (2026) studied this question.

synapsesocial.com/papers/699010ce2ccff479cfe56f89 https://doi.org/10.1212/nxi.0000000000200548

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Complement Inhibition for Acute Neuromyelitis Optica Spectrum Disorder Attacks

Key Points

Implication

Abstract

Discussion

Cite This Study

Complement Inhibition for Acute Neuromyelitis Optica Spectrum Disorder Attacks

Key Points

Implication

Abstract

Discussion

Cite This Study

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