What question did this study set out to answer?

This research aims to explore how high-protein diets affect gut microbiota and barrier function differently in male and female piglets.

February 14, 2026European Journal of NutritionOpen Access

High-protein diets increase microbiota associated p-cresol production in the colon and reduce gut barrier function in a sex-dependent manner

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Authors

DJDaniel JamesUniversity of Reading MBMaria BatoolUniversity of Reading CPCarlos Poveda

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Implication

Research reports that high-protein diets affect gut barrier function sexually dimorphically in piglets, suggesting the need for tailored nutritional strategies.

Key Points

This research aims to explore how high-protein diets affect gut microbiota and barrier function differently in male and female piglets.
Fed male and female piglets high-protein or standard-protein diets for four weeks.
Used 16 S rRNA sequencing to assess bacterial populations.
Measured urinary metabolites using SPME/GC-MS.
Analyzed gut barrier proteins through quantitative fluorescence immunohistology.
High-protein diets increased p-cresol production from gut bacteria.
Barrier proteins E-cadherin and CD45+ expression decreased in response to high-protein diets.
Females on high-protein diets showed higher levels of Staphylococcus and Chryseobacterium compared to males.
Female piglets had reduced expression of ZO-1 protein compared to their male counterparts.

Cite This Study

James et al. (2026) studied this question.

synapsesocial.com/papers/699010ce2ccff479cfe57024 https://doi.org/10.1007/s00394-025-03885-6

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Implication

Research reports that high-protein diets affect gut barrier function sexually dimorphically in piglets, suggesting the need for tailored nutritional strategies.

High-protein diets increase microbiota associated p-cresol production in the colon and reduce gut barrier function in a sex-dependent manner

Discussion

Member takes

Implication

Key Points

Cite This Study

High-protein diets increase microbiota associated p-cresol production in the colon and reduce gut barrier function in a sex-dependent manner

Discussion

Member takes

Implication

Key Points

Cite This Study

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