Cohort study finds CSF HIV viral escape linked to improved neurocognitive outcomes in meningitis survivors, suggesting potential therapeutic implications.
Among this prospective cohort of 93 Ugandan adults who survived HIV-associated cryptococcal or tuberculous meningitis, baseline secondary cerebrospinal fluid (CSF) HIV viral escape was highly prevalent and was associated with better neurocognitive outcomes at 3 months. Individuals with secondary CSF HIV viral escape were more likely to be antiretroviral therapy–naïve and to exhibit CSF pleocytosis.
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Nsangi et al. (2026) studied this question.
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