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February 14, 2026Chemical Communications

Development of Covalent Inhibitors for Bacterial Histidine Kinases

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Authors

PRPatricia RodríguezUniversity of MinnesotaCFConrad FihnMGManibarsha GoswamiUniversity of Minnesota

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Implication

Antivirulence therapies developed to inhibit bacterial histidine kinases, suggesting new strategies against resistance.

Key Points

  • To develop covalent inhibitors targeting bacterial histidine kinases as a novel treatment strategy against antimicrobial resistance.
  • Synthesized 2-aminobenzothiazole sulfonyl fluoride analogs
  • Conducted in vitro assays to evaluate inhibitor efficacy
  • Performed in cellulo assays for effectiveness in biological systems
  • Identified strong lead inhibitors for bacterial histidine kinases
  • Validated the potential of antivirulence therapies against antimicrobial resistance
  • Demonstrated successful inhibition of kinases in vitro and in cellulo

Cite This Study

Rodríguez et al. (2026) studied this question.

synapsesocial.com/papers/699011032ccff479cfe5770ahttps://doi.org/10.1039/d5cc06657c
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