What question did this study set out to answer?

This study investigates how specific amino acids, Asn7 and Trp67, influence the ferryl haem form of IsdG in Staphylococcus aureus.

February 14, 2026Dalton Transactions0 citations

The roles of Asn7 and Trp67 in tuning the ferryl haem form of Staphylococcus aureus IsdG

AGAarzoo GroverUniversity of Vermont ANA. NabiUniversity of Vermont MCM. A. CongerUniversity of Vermont

Key Points

This study investigates how specific amino acids, Asn7 and Trp67, influence the ferryl haem form of IsdG in Staphylococcus aureus.
Analyzed the W67F IsdG variant.
Compared products of W67F IsdG with wild-type enzyme.
Evaluated the formation of biliverdin and staphylobilin.
W67F IsdG produces biliverdin, while wild-type produces staphylobilin.
The presence of an organic radical in the ferryl form was confirmed.

Abstract

The ferryl haem form of W67F IsdG contains an organic radical. This variant yields a biliverdin product, distinct from the staphylobilin product of wild-type enzyme.

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Cite This Study

Grover et al. (Thu,) studied this question.

synapsesocial.com/papers/6990112b2ccff479cfe57a04 https://doi.org/https://doi.org/10.1039/d5dt02793d

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