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February 14, 2026Prenatal DiagnosisOpen Access

Open Fetal Versus Postnatal Repair of Spina Bifida Aperta—A Comparison of Neonatal Outcomes

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Authors

SBSerena BanhGreat Ormond Street HospitalASAmparo SáenzGarrahan HospitalSMSofia Mastrodima‐PolychroniouUniversity College Hospital

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Implication

Retrospective study compares neonatal outcomes of fetal and postnatal repair of open spina bifida, indicating distinct treatment effects.

Key Points

  • This research aims to compare the 30-day outcomes of infants undergoing fetal versus postnatal repair of open spina bifida.
  • Retrospective analysis of patients who underwent myelomeningocele repair from 2018 to 2022
  • Eligibility based on criteria from the MOMS trial for fetal surgery
  • Primary outcomes included cerebrospinal fluid complications, motor function, and wound complications
  • Postnatal repairs resulted in higher mean birth weight and gestational age at delivery
  • Fetal repair associated with lower rates of hydrocephalus treatment and cerebrospinal fluid leaks
  • Respiratory distress syndrome was more frequent in infants with fetal surgery

Cite This Study

Banh et al. (2026) studied this question.

synapsesocial.com/papers/699011522ccff479cfe57d24https://doi.org/10.1002/pd.70088
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele2011 · 2,267 citations
  2. 2Length of hysterotomy for fetal spina bifida repair is associated with prematurity risk2024 · 4 citations
  3. 3Fetal Myelomeningocele Repair through a Mini-Hysterotomy2016 · 72 citations
  4. 4Fetal wound healing2003 · 271 citations
  5. 5‘We did everything we could’– a qualitative study exploring the acceptability of maternal‐fetal surgery for spina bifida to parents2021 · 35 citations