What question did this study set out to answer?

To explore the characteristics and impact of disseminated intravascular coagulation on patient outcomes across various critical illness causes.

February 14, 2026Thrombosis and HaemostasisOpen Access

Clinical Heterogeneity and Prognostic Impact of Disseminated Intravascular Coagulation in Critically Ill Patients: A Large-Scale Retrospective Study

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Authors

MHMariko HayamizuHokkaido University Hospital MHMineji HayakawaSapporo City General Hospital

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Implication

This large-scale retrospective study examines DIC's effects on patient mortality in critically ill individuals, indicating varied outcomes based on underlying diseases.

Key Points

To explore the characteristics and impact of disseminated intravascular coagulation on patient outcomes across various critical illness causes.
Conducted a retrospective observational study at a single center.
Included data from 1,665 critically ill patients over approximately 12 years.
Categorized patients based on underlying diseases such as cardiac arrest, sepsis, trauma, burn, and heat stroke.
Collected laboratory results and DIC scores alongside in-hospital mortality rates.
Observed significant heterogeneity in coagulation/fibrinolysis findings based on underlying diseases (p < 0.001).
Trauma-associated DIC patients had increased D-dimer and degradation product levels.
Burn-associated DIC showed higher platelet counts and decreasing antithrombin activity post-admission.
Development of DIC significantly increased in-hospital mortality, especially in trauma and burn patients.

Cite This Study

Hayamizu et al. (2026) studied this question.

synapsesocial.com/papers/699011522ccff479cfe57de7 https://doi.org/10.1055/a-2802-3753

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Implication

This large-scale retrospective study examines DIC's effects on patient mortality in critically ill individuals, indicating varied outcomes based on underlying diseases.

Clinical Heterogeneity and Prognostic Impact of Disseminated Intravascular Coagulation in Critically Ill Patients: A Large-Scale Retrospective Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Clinical Heterogeneity and Prognostic Impact of Disseminated Intravascular Coagulation in Critically Ill Patients: A Large-Scale Retrospective Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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