Research highlights oxidative stress and miRNA involvement in retinal dysfunction in Alzheimer's disease, suggesting new treatment paths.
The present findings confirm and expand our knowledge of the retinal disease in 5xFAD mice, and highlight that neuroinflammation, oxidative stress, and microgliosis participate in AD pathogenesis. The relationship between deregulated miRNAs and AD progression may open the field to miRNA-based strategies to slow down retinal dysfunction in AD.
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Guidotti et al. (2026) studied this question.
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