Stereotactic Radiosurgery Dose Reduction for Patients With Brain Metastases From Non–Small Cell Lung Primary on Immunotherapy or Targeted Therapy

Jared H. Chung; Salem M. Tos; Georgios Mantziaris; Yuki Shinya; Bardia Hajikarimloo; Jack Guiry; Abhinav Kareddy; Tanvika Vegiraju; Edward Llinas; David R. Penberthy; Zhiyuan Xu; Ryan D. Gentzler; Camilo E. Fadul; Jason P. Sheehan

doi:10.1227/neu.0000000000003961

February 12, 2026Neurosurgery

Stereotactic Radiosurgery Dose Reduction for Patients With Brain Metastases From Non–Small Cell Lung Primary on Immunotherapy or Targeted Therapy

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Key Points

The aim is to evaluate if lower doses of stereotactic radiosurgery can maintain efficacy while reducing side effects for brain metastases from non-small cell lung cancer.
Conducted a retrospective study of 264 patients with lung cancer brain metastases treated with SRS.
Used propensity score matching to compare a higher-dose group with a reduced-dose group among patients on concurrent therapy.
Analyzed adverse radiation events and local control rates of brain metastases after treatment.
Significantly fewer adverse radiation events in the reduced-dose group (10.8%) compared to the higher-dose group (23.7%).
Local control rates were similar, with 94.6% in the reduced-dose group compared to 90.3% in the higher-dose group.
Cumulative progression rates at 1, 3, and 5 years were comparable between groups.

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Implication

Retrospective study evaluates dose reduction in stereotactic radiosurgery for brain metastases, indicating improved safety without lost effectiveness.

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Cite This Study

Chung et al. (2026) studied this question.

synapsesocial.com/papers/699011602ccff479cfe58043 https://doi.org/10.1227/neu.0000000000003961

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Stereotactic Radiosurgery Dose Reduction for Patients With Brain Metastases From Non–Small Cell Lung Primary on Immunotherapy or Targeted Therapy

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Stereotactic Radiosurgery Dose Reduction for Patients With Brain Metastases From Non–Small Cell Lung Primary on Immunotherapy or Targeted Therapy

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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