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The aim is to investigate how mitochondrial dysfunction affects IgA-secreting plasma cells in Crohn's disease.

February 14, 2026Nature CommunicationsOpen Access

Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn’s disease

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The aim is to investigate how mitochondrial dysfunction affects IgA-secreting plasma cells in Crohn's disease.
Phenotyped colonic plasma cell differentiation at the single-cell level.
Utilized experimental mouse models with mitochondrial defects and dietary interventions.
Conducted RNA-seq and spatial single-cell proteomics analysis.
Crohn's disease patients in remission show significantly reduced dimeric IgA and fecal SIgA.
Increased immature plasma cells (PC) observed, while mature PC phenotype decreased.
Data indicate impaired maturation ability of CD-derived PCs into dimeric IgA-secreting cells.

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Demonstrates impaired dimeric IgA secretion in Crohn's disease, suggesting mitochondrial roles in humoral immunity.

Raschdorf et al. (2026) studied this question.

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