Childhood Maltreatment Predicts Unfavorable Course of Illness and Treatment Outcome in Depression: A Meta-Analysis

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Key Points

To determine the relationship between childhood maltreatment and the long-term clinical trajectory and therapeutic response in patients with depression.
Conducted a systematic meta-analysis of clinical studies evaluating the effects of childhood maltreatment in depression.
Synthesized observational and clinical data assessing longitudinal disease trajectory, persistence, and treatment response.
Childhood maltreatment significantly and consistently predicts an unfavorable, protracted, or recurrent course of depressive illness.
A history of maltreatment is associated with diminished therapeutic efficacy and worse overall treatment outcomes across depressive interventions.

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Meta-analysis reveals unfavorable illness course and treatment outcomes in depression, highlighting the clinical necessity of trauma-informed care.

Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression.

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Nanni et al. (2011) studied this question.

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