Why the study?
Obesity predisposes to cardiovascular events and increases mortality, prompting a comprehensive evaluation of the protective effect of bariatric surgery on disease-specific mortality and major adverse cardiovascular events in patients with severe obesity.
Does bariatric surgery reduce disease-specific mortality and major adverse cardiovascular events in patients with severe obesity?
Population
Patients with severe obesity across 40 matched cohort studies
Comparison
Bariatric surgery vs nonsurgical controls matched by age, sex, and BMI
Design
Meta-analysis of age, sex, and BMI-matched cohort studies
Authors
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May support bariatric surgery for CV risk reduction in severe obesity; extends observational meta-analytic evidence but requires RCTs.
Does bariatric surgery reduce disease-specific mortality and major adverse cardiovascular events in patients with severe obesity?
Bariatric surgery significantly reduces cardiovascular mortality and major adverse cardiovascular events in patients with severe obesity, with greater mortality benefit seen in those with concurrent type 2 diabetes.
Cui et al. (2023) studied this question.