What question did this study set out to answer?

This research aimed to explore the relationship between eosinophilic airway inflammation and clinical severity in bronchiectasis.

February 16, 2026Thorax

Clinical, molecular and microbial characterisation of the eosinophilic endotype of bronchiectasis: data from the EMBARC-BRIDGE study

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This research aimed to explore the relationship between eosinophilic airway inflammation and clinical severity in bronchiectasis.
Utilised sputum from 180 stable patients with CT-confirmed bronchiectasis
Analyzed levels of eosinophil proteins using liquid chromatography-tandem mass spectrometry
Conducted nested analysis of patients based on blood eosinophil count (BEC)
Found weak associations between eosinophil proteins and bronchiectasis severity
Identified significant differences in sputum PCR-positivity for Pseudomonas aeruginosa between eosinophilic groups
Noted no differences in inflammatory biomarkers between groups

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Implication

Investigations reveal biomarkers related to clinical severity in bronchiectasis with Pseudomonas aeruginosa infection indicating complex immunological interactions.

Cite This Study

Pollock et al. (2026) studied this question.

synapsesocial.com/papers/699264d1eb1f82dc367a0a3c https://doi.org/10.1136/thorax-2025-223305

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Implication

Investigations reveal biomarkers related to clinical severity in bronchiectasis with Pseudomonas aeruginosa infection indicating complex immunological interactions.

Clinical, molecular and microbial characterisation of the eosinophilic endotype of bronchiectasis: data from the EMBARC-BRIDGE study

Key Points

Discussion

Implication

Cite This Study

Clinical, molecular and microbial characterisation of the eosinophilic endotype of bronchiectasis: data from the EMBARC-BRIDGE study

Key Points

Discussion

Implication

Cite This Study

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