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February 16, 2026

Novel Therapeutic Approaches for Treating Moderate-to-Severe Atopic Dermatitis in Infants with Polyvalent Allergic Sensitisation.

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Authors

MLMaria Zofia LisieckaMedical University of Warsaw

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Implication

Randomised controlled trial showed combined therapy enhances therapeutic efficacy in infants with atopic dermatitis, indicating gut microbiota restoration.

Key Points

  • This research evaluates the efficacy of a combined therapy for infants with atopic dermatitis and multiple allergic sensitisation.
  • Conducted a randomised controlled trial with 87 infants aged 3 to 12 months
  • Divided participants into experimental and control groups
  • Administered combined therapy (pseudoceramides, calcineurin inhibitor, oral synbiotic) to the experimental group
  • Evaluated outcomes using SCORAD index, VAS scale for pruritus, and POEM score
  • Experimental group showed over 60% reduction in SCORAD index by week eight
  • 2.7-fold decrease in pruritus severity reported on the VAS scale
  • Significant reduction in IL-13 levels and overall IgE levels
  • Improved gut microbiota, including increased Bifidobacterium spp. abundance and reduced E. coli levels

Cite This Study

Maria Zofia Lisiecka (2026) studied this question.

synapsesocial.com/papers/699264d1eb1f82dc367a0c29https://doi.org/10.34763/jmotherandchild.20263001.d-25-00037
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A comprehensive approach to the treatment of atopic dermatitis in children with food sensitisation2025
  2. 2Comparative efficacy of pediatric atopic dermatitis treatments: a network meta-analysis highlighting dupilumab and pimecrolimus for SCORAD and EASI improvement2026
  3. 3EFFECTIVENESS OF ENHANCING THE SKIN BARRIER SINCE EARLY INFANCY TO PREVENT INFANTILE ATOPIC DERMATITIS AND FOOD SENSITIZATION: A RANDOMIZED CONTROLLED TRIAL2024
  4. 4Impact of Probiotics on Atopic Dermatitis in Pediatric Patients: A Systematic Review and Meta-Analysis2025 · 2 citations
  5. 5Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT2024 · 8 citations