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Case-control study shows serum beta defensin-2 is elevated, but doesn't correlate with disease activity in psoriasis, suggesting a role in local immune activation.
Although serum hBD-2 is elevated in psoriasis and PsA, it does not correlate with clinical or laboratory disease activity in psoriasis. These findings suggest that hBD-2 may reflect local cutaneous immune activation rather than systemic inflammation.
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Kaya et al. (2026) studied this question.
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