What question did this study set out to answer?

This research investigates the effects of aging on spatial abilities in individuals with Down syndrome and their relationship with Alzheimer's disease.

February 16, 2026Alzheimer s & Dementia

Spatial abilities in aging adults with Down syndrome

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Authors

YYYingying YangMontclair State University RBRomal BhullarMontclair State University SCSonia CondeMontclair State University

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Implication

Examination reveals spatial abilities decline with Alzheimer's disease in adults with Down syndrome, indicating key cognitive markers.

Key Points

This research investigates the effects of aging on spatial abilities in individuals with Down syndrome and their relationship with Alzheimer's disease.
Participants included 376 individuals with Down syndrome from the Alzheimer's Biomarkers Consortium–Down Syndrome project.
Participants completed a series of cognitive measures assessing spatial abilities.
Age effects were analyzed in both visuospatial construction and visuomotor integration.
Visuomotor integration declined with age, while visuospatial construction showed no significant age effects.
Both abilities exhibited poor discrimination between cognitively stable and mild cognitive impairment, but better differentiation between cognitively stable and Alzheimer's disease.
Block Design exhibited the highest predictive power for distinguishing cognitive stability from Alzheimer's disease.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69926552eb1f82dc367a1427 https://doi.org/10.1002/alz.71159

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February 16, 2026Alzheimer s & Dementia

Spatial abilities in aging adults with Down syndrome

View Full Paper

Ask AI

Bookmark

Authors

YYYingying YangMontclair State University RBRomal BhullarMontclair State University SCSonia CondeMontclair State University

Discussion

Member takes

Implication

Examination reveals spatial abilities decline with Alzheimer's disease in adults with Down syndrome, indicating key cognitive markers.

Key Points

This research investigates the effects of aging on spatial abilities in individuals with Down syndrome and their relationship with Alzheimer's disease.
Participants included 376 individuals with Down syndrome from the Alzheimer's Biomarkers Consortium–Down Syndrome project.
Participants completed a series of cognitive measures assessing spatial abilities.
Age effects were analyzed in both visuospatial construction and visuomotor integration.
Visuomotor integration declined with age, while visuospatial construction showed no significant age effects.
Both abilities exhibited poor discrimination between cognitively stable and mild cognitive impairment, but better differentiation between cognitively stable and Alzheimer's disease.
Block Design exhibited the highest predictive power for distinguishing cognitive stability from Alzheimer's disease.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69926552eb1f82dc367a1427 https://doi.org/10.1002/alz.71159

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