Evaluation reveals earlier multiple sclerosis diagnosis, highlighting implications for patient management.
Use of the 2024 McDonald allows for earlier MS diagnosis, but also more frequent diagnosis including in patients with radiologically isolated syndrome. The revised criteria have similar performance across the lifespan. Limitations include the lack of data on central vein sign and kappa free light chains, and missing optic nerve assessment in some patients.
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Brownlee et al. (2026) studied this question.
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