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Uncovers the role of FOSL1 in promoting camptothecin resistance via ribosome biogenesis in non-small cell lung cancer, suggesting new therapeutic strategies.
Our study defines a FOSL1-TCOF1-ribosome axis that promotes CPT tolerance in NSCLC by maintaining HR repair. These findings provide a rationale for targeting ribosome biogenesis to enhance CPT-based treatment and highlight coordinated regulation of transcription, protein synthesis, and DNA repair under chemotherapeutic stress.
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Hao et al. (2026) studied this question.
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