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February 12, 2026Biomedicine & PharmacotherapyOpen Access

MLPH-mediated activation of dermal papilla IGF-1 signaling drives human hair shaft elongation and anagen induction

Mi Hee Kwack Eunho Kang Junsu Kim Youngheum Ji Hyeonchang Ju Chang‐Hun Lee Young Kwan Sung So Yeon Kim Cheil Moon

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Key Points

The aim is to investigate how MLPH influences hair growth through IGF-1 signaling in dermal papilla cells.
Analyzed the role of MLPH in dermal papilla cells
Examined IGF-1 signaling pathways
Investigated the link between MLPH and EPOR
MLPH enhances hair shaft elongation
Activation of IGF-1 signaling was confirmed
Promotes anagen (growth phase) induction

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Implication

Findings demonstrate MLPH activates IGF-1 signaling in dermal papilla cells, suggesting new hair growth strategies.

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Cite This Study

Kwack et al. (2026) studied this question.

synapsesocial.com/papers/6992b3769b75e639e9b08276 https://doi.org/10.1016/j.biopha.2026.119114

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