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Research reveals circular RNAs enhance immune responses in osteoarthritis, suggesting new therapeutic targets.
Our findings demonstrate a dynamically regulated circRNA landscape in OA. Specific DECs appear to orchestrate joint immunity by potentially enhancing antigen presentation and macrophage polarization, thereby facilitating T-cell activation. These results position circRNAs as unrecognized immunoregulators in OA, nominating them as candidate biomarkers or therapeutic targets for modulating the joint immune microenvironment.
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Gu et al. (2026) studied this question.
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