Design, Synthesis and Exploration of Cyclic Imides as PDE4 Inhibitors in Psoriasis

Veena K S; Pallabi Panja; Tirtha Nath; V. G. M. Naidu; Kalyan Kumar Sethi

doi:10.1039/d5md01165e

January 1, 2026RSC Medicinal Chemistry

Design, Synthesis and Exploration of Cyclic Imides as PDE4 Inhibitors in Psoriasis

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Key Points

The study aims to identify cyclic imides as new inhibitors targeting PDE4B for psoriasis treatment.
Designed and synthesized cyclic imides.
Evaluated inhibitory effects on PDE4B.
Assessed impacts on inflammatory pathways related to psoriasis.
Cyclic imides showed significant inhibition of PDE4B activity.
Demonstrated potential to modulate inflammatory markers associated with psoriasis.

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Implication

Preclinical exploration targets PDE4B to improve psoriasis therapies, suggesting a novel approach for management.

Abstract

Psoriasis is a chronic inflammatory skin disorder for which effective oral therapies remain inadequate. Selectively targeting PDE4B has attracted interest as a promising therapeutic target because it modulates inflammatory pathways...

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Cite This Study

S et al. (2026) studied this question.

synapsesocial.com/papers/6992b3ca9b75e639e9b08871 https://doi.org/10.1039/d5md01165e

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Design, Synthesis and Exploration of Cyclic Imides as PDE4 Inhibitors in Psoriasis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Design, Synthesis and Exploration of Cyclic Imides as PDE4 Inhibitors in Psoriasis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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