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February 16, 2026ACS SensorsOpen Access

Toward Enhanced Selection of Antibiotics in a Hospital Laboratory—Development of a Rapid Electrochemical Antimicrobial Sensitivity Test for Urinary Tract Infections

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Authors

HRHeather RalstonABAdrian ButterworthBCBen Clark

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Overview

This development reveals a rapid antibiotic testing method for urinary tract infections, indicating improved management and stewardship.

Key Points

  • The aim is to develop a rapid testing method for antibiotic susceptibility in urinary tract infections directly from urine samples.
  • Utilized the Microplate Dx RapidPlate platform for antibiotic susceptibility testing.
  • Employed electrochemical impedance spectroscopy to detect bacterial growth and analyze susceptibility.
  • Evaluated 89 urine samples across clinical sites in the U.K. and India.
  • Compared results against standard testing methods like VITEK 2 and disk diffusion.
  • Detected bacterial growth in 50 minutes and provided susceptibility profiles within 85 minutes.
  • Achieved 95% concordance with reference tests.
  • Demonstrated consistent performance across various clinical settings and organisms, including E. coli and Klebsiella pneumoniae.

Cite This Study

Ralston et al. (2026) studied this question.

synapsesocial.com/papers/6992b3e59b75e639e9b08b78https://doi.org/10.1021/acssensors.5c02725
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