Descriptive comparative clinical study reports neurogenic inflammation in pulp tissue following in-office bleaching agents, suggesting a need for further investigation.
The increase in NPY expression-particularly with Opalescence Boost-indicates that in-office bleaching agents can elicit measurable neurobiological responses in pulp tissue after a single application. The significant difference between the control and Opalescence Boost groups suggests a possible H2O2 concentration- or formulation-dependent effect on pulpal neuropeptide activity, underscoring the need for further research on the biological impact of bleaching treatments.
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Moreno et al. (2026) studied this question.
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