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Case report compares PET/CT scans in diagnosing rhabdomyosarcoma, suggesting improved imaging options.
A 14-year-old boy with inguinal lymphadenopathy and scrotal swelling was diagnosed with perineal rhabdomyosarcoma (RMS) via lymph node biopsy. Initial staging with 18 F-FDG PET/CT revealed hypermetabolic lymph nodes and a perineal mass overlooked on contrast-enhanced CT assessment. A complementary 68 Ga-FAPI-46 PET/CT scan demonstrated comparable lesion detection with higher target-to-background contrast in the primary tumor located in the perineum. This case highlights the diagnostic value of FAP-targeted imaging in pediatric RMS and supports its potential theranostic role in soft tissue sarcomas, expanding current understanding of FAPI avidity in this rare tumor subtype.
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Shakeri et al. (2026) studied this question.
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