Community-based study shows inflammatory markers associate with cerebral small vessel disease progression, suggesting preventive strategies.
This community-based prospective study demonstrated that elevated NLR, MLR, and SII were associated with progression of total CSVD burden and progression of white matter hyperintensity, incident lacunes, and CMBs over ∼4.7 years, supporting their potential to provide additional context for CSVD preventive considerations. Limitations include study's single-city population and the lack of dynamic changes in inflammatory markers.
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Zhang et al. (2026) studied this question.
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