FASN-mediated metabolic reprogramming drives CD4+ T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylation

Lei Ye; Xijun Wang; Junhao Yin; Huan Shi; jiayao fu; BaoLi Wang; Lingyan Zheng

doi:10.1186/s13075-026-03765-2

February 13, 2026Arthritis Research & TherapyOpen Access

FASN-mediated metabolic reprogramming drives CD4+ T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylation

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Key Points

This research aims to investigate the role of FASN in CD4+ T cell hyperactivation and its potential as a therapeutic target for Sjögren’s syndrome.
Examined the role of FASN in CD4+ T cells
Assessed the shift from glycolysis to oxidative phosphorylation (OXPHOS) with FASN inhibition
Utilized preclinical models to evaluate inflammation and disease progression
FASN drives hyperactivation of CD4+ T cells in Sjögren’s syndrome
Inhibition of FASN shifts metabolism from glycolysis to OXPHOS
Reduction in inflammation and disease symptoms observed in preclinical models

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Implication

Inhibition of FASN reduces CD4+ T cell hyperactivation in Sjögren’s syndrome, implying a potential treatment target.

Abstract

FASN drives CD4⁺ T cell hyperactivation and metabolic reprogramming in SS. Its inhibition shifts cell metabolism from glycolysis to OXPHOS, reducing inflammation and ameliorating disease in preclinical models. These results identify FASN as a potential therapeutic target for SS.

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Cite This Study

Ye et al. (2026) studied this question.

synapsesocial.com/papers/6992b4779b75e639e9b09617 https://doi.org/10.1186/s13075-026-03765-2

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FASN-mediated metabolic reprogramming drives CD4+ T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylation

Key Points

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Implication

Abstract

Discussion

Cite This Study

FASN-mediated metabolic reprogramming drives CD4+ T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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