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Case report details refractory adult-onset still disease and macrophage activation syndrome, suggesting treatment complications with glucocorticoids.
Adult-onset Still disease (AOSD) is a systemic autoimmune disorder, and most patients respond well to conventional therapies, including glucocorticoids (GCs), immunosuppressants, and biologic agents. However, a small subset of patients with severe disease remains refractory to treatment and is at risk of developing life-threatening complications.
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Li et al. (2026) studied this question.
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