Systematic review finds that various interventions improve healing rates in high-risk MRONJ patients, indicating better outcomes.
A total of 19 studies were included, involving 1064 MRONJ patients and 12 different intervention measures. The meta-analysis results showed that the included interventions improved healing rates compared to conventional surgical treatment [RR = 1.44, 95 % CI (1.20, 1.71), P < 0.001]; and reduced the incidence of MRONJ in high-risk populations [RR = 0.10, 95 % CI (0.04, 0.29), P < 0.001]. The network meta-analysis results showed that the top three wound healing rates in the probability-weighted ranking were: BMP-2 + L-PRF (89.3 %) > Hyperbaric oxygen (84.1 %) > YAG laser + LLLT (67.8 %) CONCLUSION: Based on the meta-analysis results, we found that the intervention methods included in the study were effective compared to conventional surgical treatment and prevented the incidence of MRONJ in high-risk populations. The SUCRA value showed that BMP-2 + L-PRF significantly improved the healing rate of MRONJ patients and may have good clinical application prospects.
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Zhang et al. (2026) studied this question.
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