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The research aims to understand the developmental pathways of human γδ T cells and the role of TdT in this process.

February 17, 2026Cell ReportsOpen Access

In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development

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In vivo modeling uncovers terminal deoxynucleotidyl transferase's role in Vδ2 T cell development, implying new strategies for immunotherapy.

The research aims to understand the developmental pathways of human γδ T cells and the role of TdT in this process.
Generated humanized immune system NBSGW mice reconstituted with human fetal liver HSPCs
Evaluated human γδ T cells in vivo
Assessed thymic programming and peripheral effector functions
HIS mice replicate human γδ T cell and αβ T cell development
Identify TdT as a key regulator in type 3 Vδ2 T cell development
Demonstrated potential of HIS mice for screening γδ T cell-targeting immunotherapies

La et al. (2026) studied this question.

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In vivo modeling uncovers terminal deoxynucleotidyl transferase's role in Vδ2 T cell development, implying new strategies for immunotherapy.