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February 17, 2026Open Access

Dose-Dependent Dual Effects of Gradient Ionizing Radiation on Neurocognition

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Authors

XJXiaokun JianBJBeier JiangSLSixu Li

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Overview

This review outlines dose-dependent effects of ionizing radiation on neurocognition, indicating need for neuroprotective strategies.

Key Points

  • This review aims to explore how different doses of ionizing radiation affect neurocognitive function and mechanisms involved.
  • Literature review of studies on high- and low-dose ionizing radiation effects on the central nervous system.
  • Analysis of mechanisms like DNA damage, oxidative stress, and neuroplasticity in response to radiation exposure.
  • Discussion of the shift from linear no-threshold to dynamic homeostasis models.
  • High-dose radiation leads to severe DNA damage and cognitive decline.
  • Low-dose radiation can activate protective pathways that enhance neural plasticity.
  • Future strategies should focus on neuroprotective measures and understanding low-dose radiation effects.

Cite This Study

Jian et al. (2026) studied this question.

synapsesocial.com/papers/699405494e9c9e835dfd60fchttps://doi.org/10.3390/ijms27041842
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