What question did this study set out to answer?

This study aims to investigate the relationship between NT-proBNP levels and the prevalence of sarcopenia in community-dwelling adults aged 40–74 years.

February 17, 2026

Associations Between Serum N ‐Terminal Pro‐Brain Natriuretic Peptide Levels and the Prevalence of Sarcopenia in Middle‐Aged and Older J apanese Adults: A Population‐Based Cross‐Sectional Study

Resultado clave

High serum NT-proBNP levels (≥125 pg/mL) were associated with increased odds of sarcopenia (OR 2.56), low muscle mass (OR 1.63), and low handgrip strength (OR 3.38).

Puntos clave

This study aims to investigate the relationship between NT-proBNP levels and the prevalence of sarcopenia in community-dwelling adults aged 40–74 years.
Conducted a cross-sectional analysis based on the Circulatory Risk in Communities Study
Involved 1675 Japanese residents aged 40–74 years
Measured serum NT-proBNP levels and various physical function metrics
Used multivariate-adjusted logistic regression to analyze associations.
22.6% prevalence of low skeletal muscle mass among participants
4.3% prevalence of low handgrip strength
14.3% prevalence of low walking speed
24.1% prevalence of low maximal walking speed
2.56 odds ratio of sarcopenia for highest versus lowest NT-proBNP levels.

PICO estructurado

Does elevated serum NT-proBNP associate with an increased prevalence of sarcopenia and reduced physical function in middle-aged and older adults?

Población

1,675 community-dwelling Japanese adults aged 40-74 years from the Circulatory Risk in Communities Study

Intervención

High serum NT-proBNP levels (≥ 125 pg/mL)

Comparador

Low serum NT-proBNP levels (< 55 pg/mL)

Resultado

Prevalence of sarcopenia, low skeletal muscle mass, low handgrip strength, low walking speed, and low maximal walking speed

Elevated NT-proBNP levels are significantly associated with a higher prevalence of sarcopenia and reduced physical function in middle-aged and older community-dwelling adults.

Resultado numérico

Tasa de eventos absoluta: 0% vs 0%

Resumen

ABSTRACT Aim Evidence regarding the association between heart failure and sarcopenia in middle‐aged and older community‐dwelling adults is scarce. This study aimed to examine the association between NT‐proBNP levels and sarcopenia among community‐dwelling adults aged 40–74 years. Methods This cross‐sectional study was conducted based on the Circulatory Risk in Communities Study, which involved 1675 Japanese residents aged 40–74 years. Serum N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) levels, physical function, and lifestyle information were measured. Participants were categorized according to their NT‐proBNP levels (< 55, 55–124, and ≥ 125 pg/mL). Multivariate‐adjusted logistic regression models were used to calculate the odds ratios for low skeletal muscle mass, muscle strength, walking speed, maximal walking speed, and sarcopenia according to serum NT‐proBNP levels. Results Among the analyzed participants, the prevalence was 22.6% for low skeletal muscle mass, 4.3% for low handgrip strength, 14.3% for low walking speed, 24.1% for low maximal walking speed, and 5.9% for sarcopenia. The multivariable odds ratios (95% confidence interval, p for trend) comparing the highest versus lowest groups of serum NT‐proBNP levels were 1.63 (1.07–2.49, p < 0.01) for low skeletal muscle mass, 3.38 (1.70–6.73, p < 0.01) for low handgrip strength, 1.81 (0.96–3.40, p = 0.06) for low walking speed, 1.75 (1.03–2.97, p = 0.06) for low maximal walking speed, and 2.56 (1.07–6.14, p = 0.03) for sarcopenia. Conclusions High serum NT‐proBNP levels, which are a surrogate marker for heart failure, were associated with low physical function and sarcopenia.

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