What question did this study set out to answer?

This study aims to evaluate the relevance of MCT1 and MCT4 expression in circulating tumour cells isolated from non-small cell lung cancer patients during osimertinib treatment.

February 17, 2026Therapeutic Advances in Medical OncologyOpen Access

Metabolic marker profiling of circulating tumour cells in NSCLC patients treated with osimertinib: focus on MCT1 and MCT4

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Authors

KMKarolina ManganiUniversity of Patras EPEvangelia PantazakaUniversity of Patras LELianidou ES

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Implication

Pilot study examines MCT1 and MCT4 expression in circulating tumour cells, suggesting cancer prognosis implications.

Key Points

This study aims to evaluate the relevance of MCT1 and MCT4 expression in circulating tumour cells isolated from non-small cell lung cancer patients during osimertinib treatment.
Enrolled 53 NSCLC patients at three time points (baseline, post-first cycle, and progressive disease).
Isolated circulating tumour cells using the ISET platform.
Assessed MCT1 and MCT4 expression through immunofluorescence staining and confocal microscopy.
Circulating tumour cells were detected in 75% at baseline, 40% post-first cycle, and 29% at progressive disease.
MCT1 was overexpressed in 67% of CK-positive patients at baseline and varied at other time points.
MCT4 was overexpressed in 55% at baseline and showed similar trends at later evaluations.

Cite This Study

Mangani et al. (2026) studied this question.

synapsesocial.com/papers/699405774e9c9e835dfd662d https://doi.org/10.1177/17588359261416422

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Metabolic marker profiling of circulating tumour cells in NSCLC patients treated with osimertinib: focus on MCT1 and MCT4

Discussion

Member takes

Implication

Key Points

Cite This Study

Metabolic marker profiling of circulating tumour cells in NSCLC patients treated with osimertinib: focus on MCT1 and MCT4

Discussion

Member takes

Implication

Key Points

Cite This Study

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