What question did this study set out to answer?

To analyze the long-term effects of cytoreductive surgery plus HIPEC on survival and treatment complications in ovarian cancer with peritoneal metastasis.

February 17, 2026Open Access

A Meta-Analysis on the Long-Term Impact of Cytoreductive Surgery Plus HIPEC for Ovarian Cancer with Peritoneal Metastasis: Are We on the Right Path?

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Authors

DBDan Alin BrebuVictor Babeș University of Medicine and Pharmacy Timișoara MȘMircea ȘelaruSpitalul Clinic Judeţean de Urgenţă "Pius Brînzeu" Timişoara IFIonuţ Flaviu FaurVictor Babeș University of Medicine and Pharmacy Timișoara

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Implication

A meta-analysis demonstrates improved overall survival and progression-free survival in patients with ovarian cancer, indicating potential treatment benefits.

Key Points

To analyze the long-term effects of cytoreductive surgery plus HIPEC on survival and treatment complications in ovarian cancer with peritoneal metastasis.
Conducted a systematic review and meta-analysis of studies on CRS plus HIPEC for ovarian cancer.
Searched databases including PubMed, Embase, and Web of Science for eligible studies.
Analyzed overall survival (OS), progression-free survival (PFS), and complication rates using random-effects models.
CRS plus HIPEC improved overall survival with a hazard ratio (HR) of 0.68 and progression-free survival with an HR of 0.70.
The pooled complication rate for severe complications was approximately 18%.
The completeness of cytoreduction (CC-0 rate) was found to be 87%.

Cite This Study

Brebu et al. (2026) studied this question.

synapsesocial.com/papers/699405bb4e9c9e835dfd6968 https://doi.org/10.3390/life16020335

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Implication

A meta-analysis demonstrates improved overall survival and progression-free survival in patients with ovarian cancer, indicating potential treatment benefits.

A Meta-Analysis on the Long-Term Impact of Cytoreductive Surgery Plus HIPEC for Ovarian Cancer with Peritoneal Metastasis: Are We on the Right Path?

Discussion

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Implication

Key Points

Cite This Study

A Meta-Analysis on the Long-Term Impact of Cytoreductive Surgery Plus HIPEC for Ovarian Cancer with Peritoneal Metastasis: Are We on the Right Path?

Discussion

Member takes

Implication

Key Points

Cite This Study

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