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June 13, 2007Statistics in MedicineOpen Access

Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond

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Comparison

New statistical measures based on integrated… vs Area under the receiver-operating-characteristic…

Design

Other

Authors

MPMichael J. PencinaPreventive CardiologyRARalph B. D' AgostinoBoston UniversityRARalph B. D' AgostinoBoston University

Discussion

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Implication

Not ready for clinical risk assessment; extends statistical tools for biomarker evaluation in research.

Structured PICO

I
Intervention
New statistical measures based on integrated sensitivity and specificity and reclassification tables
C
Comparator
Area under the receiver-operating-characteristic curve (AUC)
O
Outcome
Improvement in risk prediction performance

Introduces novel statistical metrics (reclassification and integrated discrimination) to evaluate the incremental predictive value of new biomarkers beyond the traditional AUC.

Cite This Study

Pencina et al. (2007) studied this question.

synapsesocial.com/papers/69955da0206d9796cebc4ec2https://doi.org/10.1002/sim.2929
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