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March 7, 2012New England Journal of MedicineOpen Access

Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

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Authors

MPMichael A. PostowMemorial Sloan Kettering Cancer CenterMCMargaret K. CallahanUniversity of ConnecticutCBChristopher A. BarkerMemorial Sloan Kettering Cancer Center

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Implication

Case report reveals immune system activation linked to tumor regression in melanoma after treatment.

Key Points

  • The research aims to explore the mechanisms behind the abscopal effect in melanoma treatment, focusing on immune activation.
  • Reported a case of melanoma treated with ipilimumab and radiotherapy.
  • Monitored temporal associations between tumor shrinkage and immune responses.
  • Assessed changes in peripheral-blood immune cells and antibody responses.
  • Observed tumor shrinkage correlated with antibody responses to NY-ESO-1 after treatment.
  • Noted changes in peripheral-blood immune cells following radiotherapy.
  • Increased antibody responses to other tumor antigens post-radiotherapy.

Cite This Study

Postow et al. (2012) studied this question.

synapsesocial.com/papers/699562f810cb51f425ec4602https://doi.org/10.1056/nejmoa1112824
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