March 17, 2011Science604 citationsOpen Access
Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure
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Structured PICO
Does a small molecule cardiac myosin activator improve cardiac function in systolic heart failure?
P
Population
Systolic Heart Failure
I
Intervention
Small molecule cardiac myosin activator
O
Outcome
Cardiac functionsurrogate
Cardiac myosin activation via a small molecule represents a potential therapeutic approach to improve cardiac function in systolic heart failure.
Abstract
A small molecule improves cardiac function by accelerating the transition of myosin into a force-producing state.
Cite This Study
Malik et al. (2011) studied this question.