Endoscopic resection of a gastrointestinal stromal tumor using a new mucosal dissection knife in combination with far-view endoscopic submucosal dissection

A 59-year-old male patient underwent a gastroscopy at the Aviation General Hospital of China Medical University, which revealed a 2. 5 cm hemispherical protrusion at the greater curvature of the antrum–body junction (Fig. 1). A further abdominal enhanced CT scan performed on admission showed an abnormal density at the greater curvature of the antrum–body junction, suggesting a high possibility of gastrointestinal stromal tumors (GISTs). Therefore, we performed far-view endoscopic submucosal dissection (FV-ESD) using a new mucosal dissection knife. Intraoperatively, a submucosal tumor measuring approximately 2. 1 × 1. 8 × 1. 5 cm was found in the greater curvature of the antrum–body junction (Fig. 2 a). After submucosal injection with an endoscopic needle at the oral side of the lesion (Fig. 2 b), a “C”-shaped incision was made in the mucosa using a new mucosal dissection knife (KangpaiTe, Beijing, China), and the lesion was gradually dissected (Fig. 2 c). Finally, the wound was closed with metallic clips (Fig. 2 d–f, Video 1). The operation lasted approximately 20 minutes with an estimated blood loss of 10 mL. The patient received supportive treatments and was discharged 4 days later uneventfully. The final histopathology combined with immunophenotype confirms the GIST (Fig. 3). ESD has limitations in its application due to its complex operation, long surgical duration, and high risk of complications 1 2 3 4. A new mucosal dissection knife and the corresponding new technique (FV-ESD) designed can overcome the limitations of traditional ESD knives 5. FV-ESD obviates a transparent cap, and only the knife tip is inserted to complete the procedure. This is the first case of using FV-ESD with a new mucosal dissection knife to complete GIST ESD in a simple, fast, and safe way. FV-ESD combined with a new mucosal dissection knife may be an effective method for treating GISTs and is worthy of further study and summary. EndoscopyUCTNCodeTTT₁AO₂AG₃AD Article published online: 17 February 2026 © 2026. The Author (s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https: //creativecommons. org/licenses/by/4. 0/). Georg Thieme Verlag KG Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany