Study reveals lncRNA HOXC-AS3 regulates chondrocyte health in osteoarthritis, highlighting potential new treatments.
This study establishes lncRNA HOXC-AS3 as a key regulator of chondrocyte homeostasis that mitigates OA progression via dual mechanisms-miR-615-3p sponging and RRBP1 interaction-both of which maintain CIT expression. These findings advance the understanding of the molecular networks underlying OA pathogenesis and underscore HOXC-AS3 and its downstream signaling axis as promising therapeutic targets for OA intervention.
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Wang et al. (2026) studied this question.
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