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January 1, 2026Food & FunctionOpen Access

An in vitro screening method for probiotics with antidepressant-like effect using the enterochromaffin cell model

Peijun Tian Hao Zhu Renying Zou Qinming Kong Mengshu Xu Jianxin Zhao Hao Zhang Wei Chen Gang Wang

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Key Points

To develop a method for screening probiotics for their antidepressant-like effects using a specific cell model.
Developed an in vitro screening method
Utilized enterochromaffin cell model
Assessed the antidepressant-like effects of various probiotics
Identified specific probiotics with significant antidepressant-like effects
Demonstrated the applicability of the enterochromaffin cell model for screening
Provided a new approach for potential dietary treatments for depression

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Implication

In vitro screening identifies probiotics with antidepressant effects using the enterochromaffin cell model, suggesting potential treatments.

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Cite This Study

Tian et al. (2026) studied this question.

synapsesocial.com/papers/6996a77aecb39a600b3ed34b https://doi.org/10.1039/d6fo90016j

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Expression of concern: An <i>in vitro</i> screening method for probiotics with antidepressant-like effect using the enterochromaffin cell model2025
2Ingestion of <i>Bifidobacterium longum</i> subspecies <i>infantis</i> strain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced depressive mice through reshaping the gut microbiotaOriginal Research · 2026
3Expression of concern: Ingestion of <i>Bifidobacterium longum</i> subspecies <i>infantis</i> strain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced depressive mice through reshaping the gut microbiota2025
4Anxiolytic and Antidepressant‐Like Effects of a Probiotic Mixture HMLH123 Potentially via the Serotonergic Pathway in Wistar RatsOriginal Research · 2026
5Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial2024

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