Computational analysis explores basicity in ring-strained molecules, highlighting the role of rearrangement stability.
G4 ab initio calculations have been used to discuss the basicity of ring-strained molecules in order to separate true basicity from stabilization by rearrangement. Proton affinity (gas phase) must respect two rules: microscopic reversibility and absence of bond breaking.
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Elguero et al. (2026) studied this question.
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