Radical enzymatic peptide cyclization in natural product biosynthesis

Key Points

• The paper aims to discuss the role of radical enzymes in the cyclization of cyclic peptide natural products.
• Review of existing literature on radical enzymes and cyclic peptides.
• Analysis of different enzyme families involved in cyclization.
• Discussion of their significance in drug discovery.
• Radical enzymes produce a variety of unique cyclic peptides.
• Different enzyme families contribute to diverse macrocycle formations.
• Cyclic peptides are emphasized as important scaffolds for future drug development.