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Findings reveal altered hemodynamic response to vasopressin in obese septic shock patients, suggesting physiological resistance.
In septic shock patients, obesity is associated with increased NE requirement after AVP initiation, in contrast to the reduction observed in normal weight patients. Obesity-related resistance to AVP may be driven by intrinsic physiological factors rather than insufficient dosing.
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Melchers et al. (2026) studied this question.
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